Celebrex belongs to a group of medicines known as non-steroidal anti-inflammatory drugs, used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). It is also used to treat juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Celebrex is also used to treat painful menstrual periods and to relieve other types of short term pain including pain caused by injuries, surgery and other medical or dental procedures, or medical conditions that last for a limited time. Celebrex is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body's production of a substance that causes pain and inflammation.
Celebrex comes as a capsule to take by mouth. It is usually taken once or twice a day. If you are taking up to 200 mg of Celebrex at a time, you may take the medication with or without food. If you are taking more than 200 mg of Celebrex at a time, you should take the medication with food. Ask your doctor or pharmacist if you are not sure if you need to take your medication with food. To help you remember to take Celebrex, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Celebrex exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you cannot swallow the capsules or if you are giving this medication to a child, you may open the capsules and sprinkle the contents over a teaspoon of cold or room temperature applesauce. You may prepare the mixture in advance and store it for up to 6 hours in a refrigerator. When you are ready to take your medication, swallow all of the mixture. Then drink water to wash down the mixture and be sure that you have swallowed all of it.
Celebrex is also sometimes used with surgery and other treatments to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). Talk to your doctor about the risks of using this medication for your condition.
Tell your doctor and pharmacist if you are allergic to Celebrex, aspirin or other nsaids such as ibuprofen and naproxen, sulfa medications, any other medications, or any of the inactive ingredients in Celebrex capsules. Ask your pharmacist for a list of the inactive ingredients. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the important warning section and any of the following: angiotensin-converting enzyme inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril; angiotensin ii receptor antagonists such as candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, and valsartan; anticoagulants such as warfarin;diuretics; fluconazole; and lithium. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor if you have or have ever had any of the conditions mentioned in the important warning section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps; swelling of the hands, arms, feet, ankles, or lower legs; or liver or kidney disease. Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking Celebrex, call your doctor. If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Celebrex.
Follow the directions for using this medicine provided by your doctor. Take Celebrex exactly as directed.
The usual dosage is:
For osteoarthritis - 200 mg once daily or 100 mg twice daily.
For rheumatoid arthritis - 100 to 200 mg twice daily.
For juvenile rheumatoid arthritis: 50 mg twice daily in patients 10-25 kg, 100 mg twice daily in patients more than 25 kg
For ankylosing spondylitis - 200 mg once daily single dose or 100 mg twicedaily. If no effect is observed after 6 weeks, a trial of 400 mg (single or divided doses) may be of benefit.
For acute pain and primary dysmenorrhea - 400 mg initially, followed by 200 mg dose if needed on first day. On subsequent days, 200 mg twice daily as needed.
For familial adenomatous polyposis: 400 mg twice daily with food, as an adjunct to usual care.
Celebrex may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the important warning section, call your doctor immediately. Do not take any more Celebrex until you speak to your doctor.
Celebrex may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Celebrex have principally analgesic, antipyretic, and anti-inflammatory actions. Celebrex do not bind to opioid receptors and not classified under the Controlled Substances.