Learn about Indocin (Indomethacin), dosing, proper use and what to know before beginning treatment.
Indocin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Indocin is also used to treat pain in the shoulder caused by bursitis and tendinitis. Indocin immediate-release capsules, suspension and suppositories are also used to treat acute gouty arthritis. Indocin is in a class of medications called NSAIDs. Indocin (Tivorbex) works by stopping the body's production of a substance that causes pain, fever, and inflammation. Indocin is also sometimes used to relieve fever, pain, and inflammation caused by many types of conditions or injuries, to reduce the amount of calcium in the blood, and to treat a certain type of low blood pressure.
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Indocin, generic indomethacin, is a non-steroidal anti-inflammatory agent that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes. Indocin have principally analgesic, antipyretic, and anti-inflammatory actions. Indocin do not bind to opioid receptors and not classified under the Controlled Substances.
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Indocin comes as a capsule, an extended-release (long-acting) capsule, and a suspension to take by mouth and as a suppository to be used rectally. Indocin capsules and liquid usually are taken two to four times a day. Indocin suppositories usually are used two to four times daily. Extended-release capsules are usually taken one or two times a day. Indocin capsules, extended-release capsules, and suspension should be taken with food, immediately after meals, or with antacids. Take Indocin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Indocin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Before taking Indocin. Tell your doctor and pharmacist if you are allergic to indocin, aspirin or other nsaids such as ibuprofen and naproxen, any other medications, or any of the inactive ingredients in indocin capsules, suspension, extended release capsules, or suppositories. Ask your pharmacist for a list of the inactive ingredients.
Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the important warning section and any of the following: angiotensin-converting enzymeinhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril (prinivil, zestril), moexipril (univasc), perindopril (aceon), quinapril (accupril), ramipril (altace), and trandolapril (mavik);angiotensin ii receptor antagonists such as candesartan (atacand), eprosartan (teveten), irbesartan (avapro), losartan (cozaar), olmesartan (benicar), telmisartan (micardis), and valsartan (diovan); beta blockers such as atenolol (tenormin), labetalol (normodyne), metoprolol (lopressor, toprol xl), nadolol (corgard), and propranolol (inderal); cyclosporine (neoral, sandimmune); digoxin (lanoxin); diuretics ('water pills') such as triamterene (dyrenium, in dyazide); lithium (eskalith, lithobid); methotrexate (rheumatrex); phenytoin (dilantin); and probenecid (benemid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Tell your doctor if you have or have ever had asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); seizures; parkinson's disease; depression or mental illness; or liver or kidney disease. If you will be using indocin suppositories, also tell your doctor if you have or have ever had proctitis (inflammation of the rectum) or have or have recently had rectal bleeding.
Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy; you plan to become pregnant; or you are breast-feeding. If you become pregnant while taking indocin, call your doctor. Talk to your doctor about the risks and benefits of taking indocin if you are 65 years of age or older. Older adults should not usually take indocin because it is not as safe as other medications that can be used to treat the same condition.
If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking indocin.
You should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
Talk to your doctor about the safe use of alcohol during your treatment with indocin. Alcohol can make the side effects of indocin worse.
Swallow the extended-release capsules whole; do not split, chew, or crush them. Shake the suspension well before each use to mix the medication evenly. Your doctor may change the dose of your medication during your treatment. In some cases, your doctor may start you on a low dose of Indocin and gradually increase your dose, not more often than once a week. In other cases, your doctor may start you on an average dose of Indocin and decrease your dose once your symptoms are controlled. Follow these directions carefully and ask your doctor or pharmacist if you have any questions.
To use Indocin suppositories , follow these steps:
Remove the wrapper.
Dip the tip of the suppository in water.
Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
Using your finger, insert the suppository about 1 inch (2.5 centimeters) into the rectum. Hold it in place for a few moments.
Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.
You should try to keep the suppository in place and avoid having a bowel movement for 1 hour after you insert the suppository.
Indocin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the important warning section, call your doctor immediately. Do not take any more Indocin until you speak to your doctor.
It is important for you to keep a written list of all of nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Indocin when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.