Provigil (Modafinil)


Provigil is a prescription medicine used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders: narcolepsy, obstructive sleep apnea, or shift work disorder. Provigil will not cure these sleep disorders. Provigil may help the sleepiness caused by these conditions, but it may not stop all your sleepiness. Provigil does not take the place of getting enough sleep. Provigil may cause serious side effects including a serious rash or a serious allergic reaction that may affect parts of your body such as your liver or blood cells. Do not take Provigil if you are allergic to any of its ingredients or have had a rash or allergic reaction to modafinil (Provigil). Do not drive a car or do other dangerous activities until you know how Provigil affects you. You should avoid drinking alcohol.

Provigil generic

Provigil is available in a generic form called modafinil. Generic drugs are often less expensive than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths.

The mechanism through which Modafinil promotes wakefulness. Modafinil has wake-promoting actions similar to sympathomimetic agents including amphetamine and methylphenidate, although the pharmacologic profile is not identical to that of the sympathomimetic amines. Modafinil is not a direct-or indirect-acting dopamine receptor agonist. However, in vitro, Modafinil binds to the dopamine transporter and inhibits dopamine reuptake. This activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals.

How Provigil Works

Provigil (Modafinil), a unique wake-promoting drug. The demonstration of the wake-promoting activity of modafinil led to its therapeutic use in narcolepsy and idiopathic hypersomnia. In healthy adults, Provigil improves fatigue levels, motivation, reaction time and vigilance. Modafinil even improves brain function in sleep deprived doctors. Most powerful and popular cognitive enhancers. Supports memory, attentiveness, mood and improved mental performance. Boost focus, motivation and energy.

Provigil reviews often state that this supplement gives them a much cleaner energy boost than caffeine and other stimulants. For this reason, it has become popular for off-label use as a concentration enhancer.

Provigil has been shown to help people stay awake and active, as well as make their mind much clearer if their memory has been previously worsened by the onset of sleep deprivation. Studies have successfully shown a correlation between the use of this drug and retaining cognitive function in a healthy state against factors like a lack of sleep. However, not all of them could connect Provigil to an improvement in psychomotor function in human test subjects.

How Provigil works to help increase wakefulness and decrease sleepiness isn't clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain. These actions may result in stimulation of brain activities, which could make you feel less tired. How long does it take to work? Provigil begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.


The recommended dosage of Provigil for patients with narcolepsy is 200 mg taken orally once a day as a single dose in the morning. Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day dose.

The recommended dosage of Provigil for patients with SWD is 200 mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift.

Dosage Modifications in Patients with Severe Hepatic Impairment. In patients with severe hepatic impairment, the dosage of Provigil should be reduced to one-half of that recommended for patients with normal hepatic function. Consideration should be given to the use of lower doses and close monitoring in geriatric patients.

Buy Provigil

Modafinil is available in more than 20 countries and is marketed under the brand name Provigil in the United States, United Kingdom. Provigil is available in other countries under the other brand names.

Buying Provigil indicated in the following conditions:

Due to its appetite suppressing effects and boosted energy levels, Provigil may also be useful for losing weight. It will also allows you to push harder through your pain barrier, so can allow you to work out more intensely. Provigil wakefulness promoting effects are useful for anyone who is required to work unusual shifts. Or for those who must work attentively for long periods of time. Clinically, it is prescribed to people who suffer from narcolepsy, obstructive sleep apnea and other sleep-related disorders. There is, however, a large online pharmacy market from which many users are able to buy Provigil without a prescription internationally.

Provigil is also of a high interest to the US military for enhancing alertness and reducing battle fatigue. Availability of Provigil as a lifestyle drug is increasing, namely as a non-prescription medicine for healthy people. More students or hard-working professionals will use it for a late night's work, if it can easily be purchased. In fact, it is sold legally in on-line pharmacies. Provigil is distinct from other psychostimulants in that it does not seem to accompany any side effects, and this might encourage healthy people to use it whenever they want to.

Provigil for weight loss

Provigil is sometimes used off-label for uses that are not FDA-approved. Off-label use means the drug has been approved for one use, but is used for another. In other cases, Provigil may be misused for purposes that are not approved. Provigil can cause loss of appetite in some people who take it. Because of this side effect, some people misuse Provigil as a weight loss aid.

Provigil for depression

Provigil is used off-label for depression in people for whom antidepressants alone don't fully treat their condition. Taking Provigil along with antidepressants has been shownTrusted Source to improve symptoms of fatigue and excessive tiredness in people who have depression.

Provigil side effects

Provigil may cause serious side effects. Stop taking Provigil and call your doctor right away or get emergency help if you get any of the following:
a serious rash or serious allergic reaction, mental (psychiatric) symptoms, including: depression; feeling anxious; hearing, seeing, feeling, or sensing things that are not really there (hallucinations); an extreme increase in activity and talking (mania); thoughts of suicide; aggressive behavior, and other mental problems, symptoms of a heart problem, including chest pain, abnormal heart beats, and trouble breathing. Common side effects of Provigil include headache, nausea, dizziness, and trouble sleeping.

Modafinil (Provigil) and Armodafinil (Nuvigil) Warnings

In June 2019, drug regulators in Canada issued important notices to health care professionals regarding new evidence of an increased risk of congenital birth defects associated with use of the wakefulness stimulant drugs modafinil (Provigil) and armodafinil (Nuvigil). The notices warned that modafinil should never be used by women who are or may become pregnant. They also emphasized the need for a negative pregnancy test within one week of starting modafinil and for effective contraception during treatment with the drug and for two months after stopping it. Importantly, the notices also warned that modafinil may reduce the effectiveness of oral contraceptives. Therefore, alternative or additional contraceptive methods are required for women during treatment with modafinil and for two months after stopping the drug.


Provigil usually provides a mood and wakefulness boost, from individual reports published online, and might even reduce brain fog. Provigil still remains popular among competitive workplaces and universities. Provigil is also used by astronauts to combat fatigue, improve focus, and help adjust circadian rhythm in an artificial lighting environment.

Improve attention during fatigue

Provigil improved attention in well-rested individuals, while maintaining wakefulness, memory, and executive functions in sleep-deprived individuals compared to placebo, as shown by a meta-analysis of human studies.

Improve working memory

Provigil improved attention in well-rested individuals, while maintaining wakefulness, memory, and executive functions in sleep-deprived individuals compared to placebo, as shown by a meta-analysis of human studies.

Athletic Performance

Provigil improved reaction time in both healthy and cognitively impaired individuals. Reaction time and cognitive functioning are key elements in athletic performance. Doping with modafinil offers an advantage in almost every sport, and such cases have been reported in sprinting.

Provigil for the treatment of pain-associated fatigue

Fatigue is a symptom that is frequently found in chronic pain patients with low back pain or neck pain. At the present time, no specific psychopharmacological treatment for this problem has been identified. Provigil is a wakefulness-promoting agent that the FDA has approved for the treatment of excessive daytime sleepiness associated with narcolepsy. There have been reports on the use of Provigil for the treatment of fatigue in various neurological syndromes. As such, Provigil treatment used for a patients with severe fatigue associated with chronic low back pain and neck pain.

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